https://www.mimilan.org/tension-band-pin-2-alt daily 0.75 2017-05-01 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493619066079-1HTE7SM1K5FYXK9C4WW5/tension-band-pin-1.png Tension Band Pin 2.0 The 2 mm Tension Band Pins were designed to recover lost sales in Japan and China. There was a perception that the pin diameter of 1.6 mm provided insufficient implant strength. The project expanded the sizes of the Tension Band Pins to 2 mm, a standard size used in those regions. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493619066079-1HTE7SM1K5FYXK9C4WW5/tension-band-pin-1.png Tension Band Pin 2.0 The 2 mm Tension Band Pins were designed to recover lost sales in Japan and China. There was a perception that the pin diameter of 1.6 mm provided insufficient implant strength. The project expanded the sizes of the Tension Band Pins to 2 mm, a standard size used in those regions. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493619097112-AXHRWK9FSBQVZIGHS9V3/tension-band-pin-2.png Tension Band Pin 2.0 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493619112411-4UDYIVPS8DBK1C55O1N6/tension-band-pin-3.png Tension Band Pin 2.0 - Tension Band Pin Snapper I took this opportunity to improve upon the visual appeal of the Tension Band Pin Snapper. I drew inspiration from Greek and Roman architectural column design. The snapper resembles Doric columns. https://www.mimilan.org/anatomic-radial-head-alt daily 0.75 2018-10-25 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493591059002-7N0MOG37HWFY5X788NVH/radial-head-1.png Anatomic Radial Head https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493591059002-7N0MOG37HWFY5X788NVH/radial-head-1.png Anatomic Radial Head https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493618856395-9467T9ATFL6NRGECJXUX/radial-head-1.png Anatomic Radial Head The Anatomic Radial Head Slide-Loc is a system I worked on from concept to launch. The implant system is designed to assemble inside the body cavity to allow for a smaller surgical incision and exposure. I worked on both the implant and the instrumentation which must coordinate for a successful surgery. Manufacturing was consulted early and often in the design, allowing me to develop a deep understanding and appreciation of many manufacturing techniques. I learned how to design for milling, turning, welding, wire EDM, Swiss, and many more processes. I also worked with technicians and quality engineers to put together inspection plans that considered the available inspection tools like thread gauges, optical comparator, gauge pins, micrometers, hardness tester, and CMM. United States Patent 9,763,792 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493618918200-90XH3KD84GT19XEYCHXQ/radial-head-2-1.png Anatomic Radial Head - Precise Anatomic Contour I designed the contour of this implant to replicate the natural anatomy of the proximal radius. I carefully scuplted each curvature, consulting with an expert surgeon. Multiple sizes were designed to fit different patients. The model was created using Creo ISDX surfacing software. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493618946164-7KIMZFBWEZPA0IWDE039/radial-head-2-2.png Anatomic Radial Head https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493618963859-RJTLI94IEU3O76573L41/radial-head-3-1.png Anatomic Radial Head - Trial Implant Mechanism The trial implant system was a devilishly tricky design to tackle. The final assembly is about the size of 10 stacked pennies. Inside, there are many features and moving parts. To ensure the design worked consistently and the parts were producible, I used a tolerance stack analysis to squeeze out and redistribute every thou, accommodating machine capability.   https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493677511076-UDZSEHL8F971M6SS6VS1/radial-head-3-2.png Anatomic Radial Head https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493618998791-SP2MP3JKWZ5HV22DTULR/radial-head-4.png Anatomic Radial Head - Surgical Retractor Working in tandem with manufacturing, I designed this retractor with consideration for bending challenges such as cracking at bend sites due to overlapping aggressive bends and spring back. The blanks and bend form were developed together. After the part was deemed satisfactory, multiple prototypes were created, inspected via CMM, and I created the CAD model according to the final produced form. This was an effort to streamline the instrument development process. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493619022445-1J1ZBFXT7C399185Y6QL/radial-head-5.png Anatomic Radial Head - Resection Measurement Tool This was the final design of the height gauge. It was my first engineering design task after I left school and was ambitious. The first versions of this tool were complex: a four bar mechanism, a slider, able to change to different thicknesses via a rocker cam component. It was a cool design, but not the best design for the task at hand. I swallowed my pride, scrapped the design and changed to this simple gap gauge concept. Learning to simplify against my better aspirations was difficult, but served me well in the long run. https://www.mimilan.org/home daily 1.0 2024-01-22 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1facd09a-24a2-4ae6-a0be-26fd8bbfdcbc/2DA03E95-0B9D-49AF-A46E-ADA8762D2A15_1_105_c.jpeg Home https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/61eb3be4-0f15-4187-827b-9de0b20a636d/vard-2.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/bcbfb3c9-7152-47c5-918e-cf68e098d80a/solved-5.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/a24076eb-8e8e-4d04-8be3-477e6cca5289/Nebulizer.png Home - Make it stand out Creare IN Nebulizer featuring disposable drug cartridges that could be used to administer other drugs https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/00239c8d-3d8b-4720-ad8d-5660cc8f8a4a/glued.png Home - Make it stand out Workflow: Glue electrodes into base of well, sterilize well-electrode construct, seed cells into each well of the 6 well plate, inject current (0 - 8 mA) for 48 hours, stain the cells with fluorescent dyes and incubate 30 minutes, using the microscope take images at locations of interest, count the cells in each location, determine if cell count is correlated with electric field strength. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/d5e52a1e-9252-46ed-ab1d-8de4296e119c/solved-3.png Home - Cell Adherence In my initial design, it often seemed like the cells had trouble adhering to the flexible PCB material and the gold plated surface, making it difficult to judge if the cells were unhappy with the injected current or were absent from a region because of poor initial attachment. By suspending the electrode array above the cellular monolayer, the cells could grow happily on the bottom of well, allowing me to isolate the effects of various AC current and frequency combinations on cell growth. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/44e15102-1b07-4c56-a074-16185d9b7e2a/suspended-setup.png Home - Make it stand out Workflow: Sterilize electrodes, seed cells into each well of the 6 well plate, after 2hr settling period, insert electrodes from above, inject current (0 - 8 mA) for 48 hours, stain the cells with fluorescent dyes and incubate 30 minutes, using the microscope take images at locations of interest, count the cells in each location, see if cell count is correlated with electric field strength. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/616839fc-2631-48c0-9840-3519a80a18ab/Screenshot+2024-01-13+at+3.29.42%E2%80%AFPM.png Home - Make it stand out Figure 1: A) An ultra-compact device for measuring urinary calcium developed under a previous NASA HERO project. B) The generation 1 optrodes developed in the previous project. This optrode featured a solid calcein and buffer coating stabilized in an ethyl-cellulose film on the internal wall of a capillary tube. Urine was drawn into the tube inner chamber by capillary action. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/fc38f313-67d3-4824-bc8b-a9d44e4391bd/solved-1.png Home - Objective Lens Collisions With the upright microscope, the objective lens would run into the edges of the six-well plate, producing images with a limited view of the small circular area in the center of the well. My removable, suspended electrode-array made the cells visible through the transparent bottom of the six-well plate, allowing me to image with the inverted microscope, free of obstruction and artifact. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789936877-CVBTTGUSQ5B5NLPVY3OG/reactor.jpeg Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/5fd527ba-0ce5-49be-ae86-a90507cc372b/live-data-demo.png Home - ARMI Live Technology Demo For this demo, I injected conductive solution bolus (blue) and insulating solution bolus (red) into the chamber and could visualize the conductivity change in realtime in Matlab. I used OBS Studio for demo, which made it look extra polished. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/ce1a9772-61e8-47fc-9673-bb452ec3ea39/vard-macro.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705194291446-AYDXKYP4Y7J24VPAHKGR/image-asset.jpeg Home Dragon capsule delivering humans to the International Space Station (ISS). One of my projects is set to fly on Dragon in 2024! https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/0ff3d68a-d8ad-40bb-9df5-ff0058af480d/Artboard+1.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/615487ef-22aa-4d7f-a570-bde2e077104e/reactor-schematic.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/c46f4ada-f719-4c1d-8242-b61ec111c5e8/Untitled.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/a47d68bd-aa35-4ca3-a9d4-3a2755546fc5/vard-3.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/8cbaaec9-fc2a-4ae3-bd2c-6e540d7208ef/test+copy.png Home Human mesenchymal stem cells, grown on a scaffold in our custom perfusion bioreactors. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/747154e0-6e66-402a-9d5a-84f867d17773/Screenshot+2024-01-13+at+10.09.40%E2%80%AFPM.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/34df8a5f-879c-4380-832f-a8878adf90ae/solved-2.png Home - Automated Cell Counting Initially I tried to develop an algorithm to count cells using cells stained only with Calcein. However, the tendency of these fibroblasts to overlap and clump made automation difficult. To make it easier for the algorithm, I decided to also stain the nuclei. This created clearly separated dots that were easily counted using simple digital image processing techniques like thresholding and watershed. Having both the cell body and the nuclei stained provided me a composite image that made manual counting easier. After manually counting a number of images by hand, I was able to verify that my algorithm was accurate! https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/fc8e828a-7c8e-4f35-9282-6a99918d3bd7/bioreactor-exploded.png Home - Third Iteration: Bioreactor My bioreactor design centered around a 3D printed cell-culture chamber where my rigid electrode array PCB could form one water tight wall of the chamber and a clear cover plate formed the other water tight wall. The 3D printed chamber contained ports to allow media to flow through, and barb geometry on either side to easily connect to 1/4 inch silicone tubing. The clear cover plates were originally laser cut from acrylic sheets for convenience, but I soon switched to polycarbonate once I discovered (on a critical experiment day) that acrylic had a tendency to crack when it came in contact with alcohol. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/b4bf8329-6698-4928-99bf-f8076c99d9a1/vard-1.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/aae801d2-8b16-468d-9da3-5607c7f7f3b6/suspened-to-bioreactor.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789934510-72J8RE7UFACK39LPW0U1/3-reactors.png Home Three parallel bioreactor units. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789939353-ONSHHMO8X08INE55XMHP/syringe.png Home - Syringe Pump Setup Initial design was set to use a syringe pump, ended up using a peristaltic pump instead. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789935619-URIK5LYJRAT1HESLEF46/peristaltic-pump.png Home Peristaltic pump motor with four pump heads. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789932803-5J5MCH6JGN2S5WZEN3BS/bubbles-leaks.png Home Bubbles and leaks were issues in our first pilot experiment using these early generation bioreactors. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789937201-QPF59GNRZRS0CFTM2QE1/scaffold-macro.png Home U251 Glioblastoma cells shown successfully seeded on the surface of a tissue scaffold made from decellularized bovine bone. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493505946231-LYOYU6G83JTMNXS3J76N/yellow.png Home https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493505963707-30FD6PFFOZC2N4I7IMYS/red.png Home https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493505982257-Z3MMK80BXN47KZEU5DM4/light-blue.png Home https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493619486723-K1Y380NBBW5F8SX6F575/mimi-tagline.png Home https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493695343086-SUVMLCPW3DGGUJ3DW048/grey.png Home https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493803018026-BAB3C6VYPE9BYHO28NLY/dark-blue.png Home https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493803119464-O6AAVTDM7XJEGBF36S1I/brownish.png Home https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705186807021-BPGLHN92CNKJC0BGJ7RZ/light-blue.png Home https://www.mimilan.org/medical-exoskeleton-alt daily 0.75 2017-05-03 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493803840277-VC9L8KMMLDOOYHRD5T9X/medical-exoskeleton-4.jpg Medical Exoskeleton Being involved in this lab and working on the exoskeleton was really challenging and drew me far out of my comfort zone, but I knew deep down I wanted to be involved. I started with few relevant skill sets, but armed with a can-do attitude and friendly demeanor, I quickly learned how much more important those traits are to the team. It was here I got my first experiences in rapid prototyping, learned about McMaster Carr, K&J magnets, Sparkfun and other resources for scrapping together bits and pieces to develop prototypes. I loved listening to the graduate students debate about control theory, how to streamline the mechanical design, optimal PCB layout, or other design issues. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493803840277-VC9L8KMMLDOOYHRD5T9X/medical-exoskeleton-4.jpg Medical Exoskeleton Being involved in this lab and working on the exoskeleton was really challenging and drew me far out of my comfort zone, but I knew deep down I wanted to be involved. I started with few relevant skill sets, but armed with a can-do attitude and friendly demeanor, I quickly learned how much more important those traits are to the team. It was here I got my first experiences in rapid prototyping, learned about McMaster Carr, K&J magnets, Sparkfun and other resources for scrapping together bits and pieces to develop prototypes. I loved listening to the graduate students debate about control theory, how to streamline the mechanical design, optimal PCB layout, or other design issues. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493797262629-QL9GTT6Q7GVC3PNKRP5Y/medical-exoskeleton-3.jpg Medical Exoskeleton https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493803839034-5BQ5JZLAJ7L2AK82L2PG/medical-exoskeleton-1.jpg Medical Exoskeleton https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493803836545-SAGP3KMH430H1WAYPC3U/medical-exoskeleton-2.jpg Medical Exoskeleton https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493803839181-KEF5IN0VUPURH4H94M5S/medical-exoskeleton-3.jpg Medical Exoskeleton https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493803839867-GUNC2OELFF1ZMRXT9Z5F/medical-exoskeleton-5.jpg Medical Exoskeleton https://www.mimilan.org/textbook-illustration daily 0.75 2017-05-03 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809239895-B63S8EBUPQ3582L6BGA8/textbook-cover.jpg Textbook Illustration Creating these illustrations was a fun undertaking in college. The figures I created were for my professor’s textbook on Biomaterials. I enjoyed having a good excuse to tinker around in Adobe Illustrator. I tried various techniques with gradient shading to give materials a feeling of depth. It was a welcome break from the engineering homework, but also a good visual communication challenge. It was a unique assignment combining two things I enjoy deeply, art and engineering. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809239895-B63S8EBUPQ3582L6BGA8/textbook-cover.jpg Textbook Illustration Creating these illustrations was a fun undertaking in college. The figures I created were for my professor’s textbook on Biomaterials. I enjoyed having a good excuse to tinker around in Adobe Illustrator. I tried various techniques with gradient shading to give materials a feeling of depth. It was a welcome break from the engineering homework, but also a good visual communication challenge. It was a unique assignment combining two things I enjoy deeply, art and engineering. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809234325-T3AKB9ZNLB7NE6LRECPP/textbook-1.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809234662-VL8L527GARZQVTE1BZON/textbook-2.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809234718-3OZKDL45PO3YFK6MTX5K/textbook-3.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809235000-V27V66CSVPARWORM6130/textbook-4.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809235786-GZHAV67Q0AV00D9GW2HB/textbook-5.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809235785-OIPN83J0RU9O2HYDI0WY/textbook-6.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809236567-DC3EO2A6BAKJOC00KUB2/textbook-7.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809236721-HPECXI0HMR7J3B6HJSWD/textbook-8.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809237145-1IB1YRZ2UXWBFSXZ0Z9J/textbook-9.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809237821-PEG4XHK3RXCKJY7NP03W/textbook-10.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809237587-6HH2NFM9YOPRA8TRB4DG/textbook-11.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809238449-BDZ9J6KAC0IPH176MOWQ/textbook-12.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809238206-VK78A0EM3D9ONP2EY9RA/textbook-13.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809239098-HR2XGDI8AY0AX8KNVMOI/textbook-14.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809239198-D7BBRBH7SOIHRI3Z5TWO/textbook-15.jpg Textbook Illustration https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493809239651-KUJPTO4H4CJF2B4FXW7V/textbook-16.jpg Textbook Illustration https://www.mimilan.org/3d-printed-art-1 daily 0.75 2017-05-02 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493698059557-GK7Y6ENTF3TZ4QF37NQN/3d-bird-in-space.jpg 3D Printed - Bird In Space Ode to Brancusi's Bird in Space, a sculpture I've long admired. Modeled in NX CAD and 3D printed in nylon for prototyping. Brass and stainless steel versions coming soon. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493698059557-GK7Y6ENTF3TZ4QF37NQN/3d-bird-in-space.jpg 3D Printed - Bird In Space Ode to Brancusi's Bird in Space, a sculpture I've long admired. Modeled in NX CAD and 3D printed in nylon for prototyping. Brass and stainless steel versions coming soon. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493698060593-WK9IO75EN6TBTB4SNSBE/3d-bunny-2.jpg 3D Printed - Sir Hop-a-Lot An exploration of Autodesk's scuplting application, Sculpt+ for iOS. This bunny has a pleasant behind, and was printed in ceramic, finished in gloss white. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493698059166-7LAFQ3COO75L751ZXODN/3d-bunny-1.jpg 3D Printed https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493698060042-3BPGMXH6CVOVRRVM3NUB/3d-bunny-3.jpg 3D Printed https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493698061739-V982TXVB5G7U4NW0JDQ4/3d-pig-3.jpg 3D Printed - Oinker This little piggy was inspired by some minimalist animal figurines I saw. Also modeled in Autodesk Sculpt+, printed in ceramic and finished in gloss white. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493698061367-EQE0QXXHVHXAM04RMTIJ/3d-pig-2.jpg 3D Printed https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493698060585-UB07F2WFP9MVMUL6FXAK/3d-pig-1.jpg 3D Printed https://www.mimilan.org/water-color daily 0.75 2018-07-20 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493690014983-1BZHD53Z7GM88FUX5HCE/water-color-chickadee.jpg Water Color https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493690014983-1BZHD53Z7GM88FUX5HCE/water-color-chickadee.jpg Water Color https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493690016382-KGXF0NSE41G86LI0TLFT/water-color-duchy.jpg Water Color https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493690016034-LC4TYPRO55K39BCIZA4Y/water-color-google-car.jpg Water Color https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493690017704-L1SGECK4FI61C8MNEYSC/water-color-mingus.jpg Water Color https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493690017558-PN9CT38X91IMMQA3WNI4/water-color-stick.jpg Water Color https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1495927519744-3TRZYO8SZXZ7ET0X0FF5/water-color-daisy.jpg Water Color https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1532121494711-R6XTEXAORPX5X5YEJ9GG/311214-072018.jpg Water Color https://www.mimilan.org/figure-drawing-alt daily 0.75 2017-05-02 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696689569-OLZERC3LPRH4MFJIUL91/figure-drawing-1.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696689569-OLZERC3LPRH4MFJIUL91/figure-drawing-1.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696751092-5QN4MM1ZQ0OLSN0UHCQD/figure-drawing-2.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696750826-4WBOYFMEA96588SGJA5L/figure-drawing-3.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696752405-E0NNQTF4FRZ5J5HUFPZ7/figure-drawing-4.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696751764-Y0O4O1709BG4BI4QYAUP/figure-drawing-5.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696752316-K2R446B0S9O2P58ZK3WR/figure-drawing-6.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696753417-RXZFEIJVBW5OXBCZLRHS/figure-drawing-7.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696753243-ZWPKNRRMYU9H4KGZMQPK/figure-drawing-8.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696755003-HGGR44K26EJUGT8FR9PW/figure-drawing-9.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696754260-D4GB7SYLYUSZKIMWBC1J/figure-drawing-10.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696755007-TQCVRXB19JVR7Y2N2SWL/figure-drawing-11.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696756842-O8SHWDL1K26YRCU8MUTO/figure-drawing-12.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696756152-ZKO34Y41CTMCJ78CVAWX/figure-drawing-13.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696756840-I78QHOF8M1OLZ36QGQPM/figure-drawing-14.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696758105-ZRDN3W181EKK90U11JIV/figure-drawing-15.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696757923-BD3QVVBHOCGK7JO7PXLD/figure-drawing-16.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696759577-LT8G8ZT4IQA0DCZ8LTBD/figure-drawing-17.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696758743-8BIMVSO7WN9938IS3H6U/figure-drawing-18.jpg Figure Drawing https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493696759530-NJ0FMB3M0DRCPUZLK8UF/figure-drawing-19.jpg Figure Drawing https://www.mimilan.org/radome-install-system-alt daily 0.75 2017-05-04 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493811213399-TM7KXFLZ4JG4S3UU0082/radome-diagram.jpg Aircraft Radome Install System This system design began as an all machined design, leveraging an extruded aluminum spine and cross beam. To reduce the cost of production, milled aluminum was switched to 3D printed nylon, drastically improving weight and lead time. This project was challenging in numerous ways. To start, multiple parties were involved—four different companies to be specific. The engineering design and development had to be carefully managed, tracked, and communicated to avoid confusion. The schedule was strenuous. We were typically given 3 weeks between iterations to come up with the designs, implement them, document it and deliver physical parts. Adding to the challenge, this was also the first design and manufacturing project for the engineering service company I worked for. This meant that as the design was created and developed, all revision control, engineering change orders, part number systems, manufacturing contacts, quality systems etc. had to be established for the first time and used immediately. Luckily I could draw from my medical device design and documentation experience to establish these systems. Additionally, I was the only engineer working on the project while also wearing the hats of people manager and project manager. These factors combined to yield a very, very difficult project. But this was my first foray into aerospace, and I gave it my full effort. By the time the final iteration of the prototype was delivered and tested, the client company granted us new contracts to design and develop installation tools for more aircraft. Below you can see the progression of the design, as well as the tool field testing. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493811213399-TM7KXFLZ4JG4S3UU0082/radome-diagram.jpg Aircraft Radome Install System This system design began as an all machined design, leveraging an extruded aluminum spine and cross beam. To reduce the cost of production, milled aluminum was switched to 3D printed nylon, drastically improving weight and lead time. This project was challenging in numerous ways. To start, multiple parties were involved—four different companies to be specific. The engineering design and development had to be carefully managed, tracked, and communicated to avoid confusion. The schedule was strenuous. We were typically given 3 weeks between iterations to come up with the designs, implement them, document it and deliver physical parts. Adding to the challenge, this was also the first design and manufacturing project for the engineering service company I worked for. This meant that as the design was created and developed, all revision control, engineering change orders, part number systems, manufacturing contacts, quality systems etc. had to be established for the first time and used immediately. Luckily I could draw from my medical device design and documentation experience to establish these systems. Additionally, I was the only engineer working on the project while also wearing the hats of people manager and project manager. These factors combined to yield a very, very difficult project. But this was my first foray into aerospace, and I gave it my full effort. By the time the final iteration of the prototype was delivered and tested, the client company granted us new contracts to design and develop installation tools for more aircraft. Below you can see the progression of the design, as well as the tool field testing. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493810769130-IU8FMBM7D7SD7KDIUXP1/radome-1.jpg Aircraft Radome Install System https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493811075885-6VGXGVQEH4XC6BD3IUZD/radome-1.jpg Aircraft Radome Install System https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493811076237-KCKHY5OA09KLV0MVCUV5/radome-2.jpg Aircraft Radome Install System https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493811076237-ZWGTIGVGOIY5JWBLNF0T/radome-3.jpg Aircraft Radome Install System https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493811076980-AF6P4E6ZV1XE0QAH5ID5/radome-4.jpg Aircraft Radome Install System https://www.mimilan.org/digital-illustration daily 0.75 2017-11-15 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1503468626633-B2F622RWGNY764A7UPER/Moe-cat.PNG Digital https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1503468626633-B2F622RWGNY764A7UPER/Moe-cat.PNG Digital https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1510728537572-ZBOV9L6E9CT2UNW3XUQ0/fullsizeoutput_363.jpeg Digital https://www.mimilan.org/about daily 0.75 2017-05-03 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1493512141765-GNH0YBVQY4VRUVLE4D9Y/mimi About Live from the stage/my workspace https://www.mimilan.org/contact daily 0.75 2017-05-03 https://www.mimilan.org/reading-log daily 0.75 2018-11-04 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1540445929309-WI5NO2AZZ9BU32EC80JL/reading-list.png Reading Log https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1540445996001-FRM7W7W9XF52BQSB9IXT/reading-list.png Reading Log https://www.mimilan.org/phd-alt daily 0.75 2024-01-22 https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/00239c8d-3d8b-4720-ad8d-5660cc8f8a4a/glued.png Ph.D. Research - Make it stand out Workflow: Glue electrodes into base of well, sterilize well-electrode construct, seed cells into each well of the 6 well plate, inject current (0 - 8 mA) and wait for 48 hours, stain the cells with fluorescent dyes and incubate 30 minutes, using the microscope take images at locations of interest, count the cells in each location, determine if cell count is correlated with electric field strength. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/615487ef-22aa-4d7f-a570-bde2e077104e/reactor-schematic.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/34df8a5f-879c-4380-832f-a8878adf90ae/solved-2.png Ph.D. Research - Automated Cell Counting Initially I had used a Live/Dead cell stain (Calcein/EthD-1), before switching to Calcein only which yielded marginally better (but still tough to automate) results. To make it easier for the algorithm to pick out cells accurately, I decided to stain the cell bodies and nuclei separately. This also allowed me to tune the two images with software before combining them into a composite image, which made counting the cells manually much more reliably accurate, if still time consuming and tedious. However, by comparing a number of manual counts to algorithmic counting of the Hoescht Channel images, I was able to validate the accuracy of the cell-counting algorithm. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/747154e0-6e66-402a-9d5a-84f867d17773/Screenshot+2024-01-13+at+10.09.40%E2%80%AFPM.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1facd09a-24a2-4ae6-a0be-26fd8bbfdcbc/2DA03E95-0B9D-49AF-A46E-ADA8762D2A15_1_105_c.jpeg Ph.D. Research https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/44e15102-1b07-4c56-a074-16185d9b7e2a/suspended-setup.png Ph.D. Research - Make it stand out Workflow: Sterilize electrodes, seed cells into each well of the 6 well plate, after 2hr settling period, insert electrodes from above, inject current (0 - 8 mA) and wait for 48 hours, stain the cells with fluorescent dyes and incubate 30 minutes, using the microscope take images at locations of interest, count the cells in each location, see if cell count is correlated with electric field strength. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/aae801d2-8b16-468d-9da3-5607c7f7f3b6/suspened-to-bioreactor.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/b4bf8329-6698-4928-99bf-f8076c99d9a1/vard-1.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/c46f4ada-f719-4c1d-8242-b61ec111c5e8/Untitled.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/fc8e828a-7c8e-4f35-9282-6a99918d3bd7/bioreactor-exploded.png Ph.D. Research - Third Iteration: Bioreactor My bioreactor design centered around a 3D printed cell-culture chamber where my rigid electrode array PCB could form one water tight wall of the chamber and a clear cover plate formed the other water tight wall. The 3D printed chamber contained ports to allow media to flow through, and male luer threads on either side to easily connect to 1/4 inch silicone tubing. The clear cover plates were originally laser cut from acrylic sheets for convenience, but I soon switched to polycarbonate once I discovered (on a critical experiment day) that acrylic had a tendency to crack when it came in contact with alcohol. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705194099280-SZLM9IIEME6XR9GO9KXJ/image-asset.jpeg Ph.D. Research Cancer cells, similar to the U-251 glioblastoma cells I used for much of my early prototyping in Ryan Halter’s lab. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/ce1a9772-61e8-47fc-9673-bb452ec3ea39/vard-macro.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789934510-72J8RE7UFACK39LPW0U1/3-reactors.png Ph.D. Research https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789939353-ONSHHMO8X08INE55XMHP/syringe.png Ph.D. Research - Syringe Pump Setup (Copy) Initial design was set to use a syringe pump, ended up using a peristaltic pump instead. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789935619-URIK5LYJRAT1HESLEF46/peristaltic-pump.png Ph.D. Research https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789932803-5J5MCH6JGN2S5WZEN3BS/bubbles-leaks.png Ph.D. Research https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789937201-QPF59GNRZRS0CFTM2QE1/scaffold-macro.png Ph.D. Research https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/a24076eb-8e8e-4d04-8be3-477e6cca5289/Nebulizer.png Ph.D. Research - Make it stand out Creare IN Nebulizer featuring disposable drug cartridges that could be used to administer other drugs https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/61eb3be4-0f15-4187-827b-9de0b20a636d/vard-2.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/bcbfb3c9-7152-47c5-918e-cf68e098d80a/solved-5.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/5fd527ba-0ce5-49be-ae86-a90507cc372b/live-data-demo.png Ph.D. Research - ARMI Live Technology Demo For this demo, I injected conductive solution bolus (blue) and insulating solution bolus (red) into the chamber and could visualize the conductivity change in realtime in Matlab. I used OBS Studio for demo, which made it look extra polished. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/616839fc-2631-48c0-9840-3519a80a18ab/Screenshot+2024-01-13+at+3.29.42%E2%80%AFPM.png Ph.D. Research - Make it stand out Figure 1: A) An ultra-compact device for measuring urinary calcium developed under a previous NASA HERO project. B) The generation 1 optrodes developed in the previous project. This optrode featured a solid calcein and buffer coating stabilized in an ethyl-cellulose film on the internal wall of a capillary tube. Urine was drawn into the tube inner chamber by capillary action. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/fc38f313-67d3-4824-bc8b-a9d44e4391bd/solved-1.png Ph.D. Research - Objective Lens Collisions With the upright microscope, the objective lens would run into the edges of the six-well plate, producing images with a limited view of the small circular area in the center of the well. My removable, suspended electrode-array made the cells visible through the transparent bottom of the six-well plate, allowing me to image with the inverted microscope, free of obstruction and artifact. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705194291446-AYDXKYP4Y7J24VPAHKGR/image-asset.jpeg Ph.D. Research Dragon capsule delivering humans to the International Space Station (ISS). One of my projects is set to fly on Dragon in 2024! https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/d5e52a1e-9252-46ed-ab1d-8de4296e119c/solved-3.png Ph.D. Research - Cell Adherence In my initial design, it often seemed like the cells had trouble adhering to the flexible PCB material and the gold plated surface, making it difficult to judge if the cells were unhappy with the injected current or were absent from a region because of poor initial attachment. By suspending the electrode array above the cellular monolayer, the cells could grow happily on the bottom of well, allowing me to isolate the effects of various AC current and frequency combinations on cell growth. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/0ff3d68a-d8ad-40bb-9df5-ff0058af480d/Artboard+1.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/a47d68bd-aa35-4ca3-a9d4-3a2755546fc5/vard-3.png Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705789936877-CVBTTGUSQ5B5NLPVY3OG/reactor.jpeg Ph.D. Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/59012d35197aeae14be5633c/1705186807021-BPGLHN92CNKJC0BGJ7RZ/light-blue.png Ph.D. Research